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sr 33805

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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SR-33805
T71223121346-32-5
SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR-33805.
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6-8 weeks
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CGS 21595
T71221121412-39-3
CGS 21595 inhibits the formation of 5-hydroxyeicosatetraenoic acid and leukotriene B4; rapidly metabolized to CGS 19213.
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6-8 weeks
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SR 33805 oxalate
T23391121346-33-6
Ca2+ channel antagonist
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10-14 weeks
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SR33805
T8674121345-64-0
SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
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