sq 14534

Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.

Epicaptopril (SQ 14534) is a derivative of Captopril and serves as an inhibitor of angiotensin-converting enzyme (ACE). It enhances vasodilation dependent on endothelium-derived relaxing factor (EDRF) and acts as a free radical scavenger. This makes it useful in studies related to oxidative stress and cardiovascular diseases caused by free radical damage.

Captopril EP Impurity E is an impurity of Captopril. Captopril, also known as SQ-14534, is an orally active angiotensin-converting enzyme (ACE) inhibitor with a thiol group, possessing antihypertensive properties, and an inhibitor constant (IC 50) of 0.025 μM.

Captopril EP Impurity B, a degradation product of Captopril (SQ-14534), serves as a thiol-containing, competitive inhibitor of the angiotensin-converting enzyme (ACE), demonstrating oral activity and potent antihypertensive effects with an IC50 value of 0.025 μM [1] [2] [3].