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(1)
By Target- Dehydrogenase
- GABA Receptor(1)
- Interleukin(1)
- NOD-like Receptor (NLR)(1)
- Pyroptosis(1)
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Results for "
songorine
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- Natural Products1
- SongorineZongorine, Napellonine, Bullatine GT5S1882509-24-0Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
- $64
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Cited - NLRP3-IN-86T2150372361570-54-7NLRP3-IN-86 (Compound 8a), a derivative of Songorine, is a potent and selective inhibitor of the NLRP3 inflammasome. It effectively reduces lactate dehydrogenase (LDH) release induced by LPS and Nigericin, with an IC50 of 2.69 μM in THP-1 cells and 1.75 μM in J774A.1 cells. Additionally, NLRP3-IN-86 inhibits the cleavage of gasdermin D (GSDMD) and the secretion of IL-1β, effectively suppressing pyroptosis. This compound is applicable for inflammation-related research.
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