somatostatin-28

Somatostatin-28 (1-12) is a fragment of somatostatin that is monitored in brain tissue to track the processing of somatostatin.

Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28, which originates from the posttranslational cleavage of prosomatostatin, derived from the larger precursor preprosomatostatin.

Tyr-Somatostatin-28 is a somatostatin derivative comprising Somatostatin-28 with an additional Tyrosine amino acid [1].

[Tyr12] Somatostatin 28 (1-14) is an analogue of the N-terminal fragment of the neuropeptide Somatostatin-28, encompassing the first 14 amino acids of the sequence.

Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-5, respectively. Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.

[Nle8] Somatostatin (1-28), a derivative of somatostatin (1-28) with norleucine (Nle) substituting for methionine at position 8, enhances amylase release and elevates cyclic AMP levels in pancreatic acini [1].

Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and

Somatostatin receptor agonist, derived from the post-translational cleavage of prosomatostatin.

Somatostatin 1-28 acetate belongs to natural products, serving as a multi-target agonist with endocrine inhibitory activity. Somatostatin 1-28 acetate circulates in human plasma, accounting for approximately 46% of total somatostatin-like immunoreactivity, and can be used for studying hormone secretion regulatory mechanisms.

[Nle8] Somatostatin (1-28) TFA is a derivative of somatostatin (1-28) where methionine at position 8 is replaced with norleucine. This compound enhances the release of amylase and increases cyclic AMP in pancreatic acini.