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sim-010603

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    3
    TargetMol | Inhibitors_Agonists
Dioxifedrine
T7157510329-60-9
Dioxifedrine is a beta-2 -adrenergic agonist with bronchodilator activity.
    6-8 weeks
    Inquiry
    SIM010603
    T715761032265-67-0
    SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.
    • Inquiry Price
    8-10 weeks
    Size
    QTY
    Tafetinib
    SIM-010603, SIM010603, SIM 010603
    T289111032265-57-8In house
    Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.
    • Inquiry Price
    6-8weeks
    Size
    QTY