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(3)
By Target- 5-HT Receptor
- Dopamine Receptor(1)
- MMP(1)
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Results for "
sb 269970
" in TargetMol Product Catalog.- Inhibitors & Agonists3
- SB-269970 hydrochlorideSB-269970A, SB269970 HClT6655261901-57-9In houseSB-269970 hydrochloride (SB-269970A) , a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
- $40
SizeQTY - SB-269970T12842201038-74-6SB-269970 is a antagonist of 5-HT7 receptor(pKi of 8.3).
- $2,370
SizeQTY - PZ-1657 hydrochlorideT214546PZ-1657 hydrochloride (Compound 57) is a potent, selective, and orally active 5-HT7 receptor inverse agonist, with a Ki value of 5 nM. It inhibits constitutive cAMP production mediated by the Gs signaling pathway, with an EC50 value of 2.93 nM. PZ-1657 hydrochloride significantly reduces 5-HT7 receptor-mediated MMP-9 activity in the mouse hippocampus, showing effects comparable to SB-269970. It reverses cognitive deficits induced by phencyclidine in a rat novel object recognition test without affecting spontaneous activity. PZ-1657 hydrochloride is useful for researching affective disorders such as depression and bipolar disorder.
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