sahp

UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker,with IC50 of 500 nM in hippocampal neurons in culture, having minimal effects on Ca2+ channels, action potentials, input resistance, and the medium afterhyperpolarization.

(S,R,S)-AHPC (VH032-NH2) is a VH032-based ligand for recruiting the von Hippel-Lindau (VHL) protein, potentially useful for the targeted degradation of the androgen receptor.

(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, suc

(S,R,S)-AHPC-O-CF3 serves as a ligand for E3 ubiquitinase and is utilized in the synthesis of PROTAC SMARCA2/4-degrader-20.

(S,R,S)-AHPC-Ala serves as a ligand for E3 ubiquitinase and is utilized in the synthesis of PROTAC SMARCA2/4-degrader-23.

(S,R,S)-AHPC-O-CF3-CO-cyclohexane serves as an E3 Ligase Ligand-Linker Conjugate and is utilized in the synthesis of PROTAC SMARCA2/4-degrader-20.

(S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin functions as an E3 Ligase Ligand-Linker Conjugate. This compound is utilized in the synthesis of PROTAC SMARCA2/4-degrader-23.

(S,R,S)-AHPC-CO-C-cyclohexane serves as an E3 Ligase Ligand-Linker Conjugate. This chemical compound is utilized in the synthesis of PROTAC SMARCA2/4-degrader-14.

(S,R,S)-AHPC-Ac serves as a ligand for E3 ubiquitinase and is utilized in the synthesis of PROTAC SMARCA2/4-degrader-22.

(S,R,S)-AHPC-p-toluic acid serves as an E3 Ligase Ligand-Linker Conjugate. This compound is utilized in the synthesis of PROTAC SMARCA2/4-degrader-18.

(S,R,S)-AHPC-phenylacetic acid, an E3 Ligase Ligand-Linker Conjugate, facilitates the synthesis of PROTAC SMARCA2/4-degrader-15.

Me-(S,R,S)-AHPC-CO-CH2-Br is an E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-linker conjugate). It is utilized in the synthesis of JNJ-1013.

6-Aminocaproic acid-(S,R,S)-AHPC-Me serves as a ligand and linker for the E3 ubiquitin ligase in PROTACs, facilitating the synthesis of PVD-06 for research in oncology.

Amino-PEG4-(S,R,S)-AHPC-Me is a ligand+linker conjugate for E3 ubiquitin ligases. It is utilized in the synthesis of PROTACNR-V04.

trans-(S,R,S)-AHPC-Me-Amide-cyclohexane-pyrimidine-Cl is an E3 ligase ligand-Linker conjugate that is utilized in the synthesis of PROTACs, such as PROTAC BRM/BRG1 degrader-2.

(S,R,S)-AHPC-Me-amide-C9-acid is an E3 ligase ligand-linker conjugate utilized in synthesizing PROTACSMARCA2 degrader-31.

Me-(S,R,S)-AHPC-PEG2-OTs is a conjugate of E3 ligase ligand and linker (E3 Ligase Ligand-Linker Conjugates) utilized in the synthesis of PROTAC HIF-1α degrader-1.

(S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide comprises a VHL ligand for recruiting E3 ubiquitin ligases and a PROTAC linker. This compound is used in synthesizing PROTACs such as MS934. MS934 represents a novel and improved VHL-recruiting MEK1/2 PROTAC degrader.

(S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) serves as a VHL ligand and is applicable in the synthesis of PROTACs [1].'

(S,R,S)-AHPC-O-PEG1-propargyl, serves as an E3 ligand essential for PROTAC [1] synthesis. Additionally, this compound functions as a click chemistry reagent equipped with an Alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules.

SMARCA2/4-ligand-Linker Conjugate-4 is an E3 ubiquitin ligase ligand-linker conjugate.

(S,R,S)-AHPC-CO-cyclohexane-C2 is a ligand-linker conjugate for E3 ubiquitin ligases.

SMARCA2-ligand-Linker Conjugate-1 is an E3 ubiquitin ligase ligand-linker conjugate.

SMARCA2/4-ligand-Linker Conjugate-7 is an E3 ubiquitin ligase ligand-linker conjugate.