ruvbl1/2 atpase-in-1

RUVBL1 2 ATPase-IN-1 is an effective RUVBL1 2 ATPase inhibitor with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 2 ATPase-IN-1 can be used in cancer disease studies.

CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1 2 complex. It specifically interacts with RUVBL1 2 in cancer cells and blocks the ATPase activity of RUVBL1 2 with a half-maximal inhibitory concentration (IC50) of 15 nM[1].

TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC).