royal jelly acid

Royal Jelly Acid (Queen Bee Acid) is a major fatty acid found in royal jelly that promotes neuronal growth and protection and reduces anxiety. Royal Jelly Acid induces reactive oxygen species (ROS)-mediated apoptosis in A549 cells, improves non-alcoholic fatty liver disease by activating the AMPK-α signaling pathway, and reduces bone loss by inhibiting the NF-κB signaling pathway downstream of FFAR4. Royal Jelly Acid also exhibits inhibitory effects against various bacteria and fungi, including Aspergillus niger, mold, and Staphylococcus aureus. By targeting aspartyl β-hydroxylase and inhibiting chondrocyte senescence, Royal Jelly Acid exerts a preventive and therapeutic effect against osteoarthritis.

Royal Jelly acid (Standard) is the standard substance of Royal Jelly acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Royal Jelly acid (Queen Bee Acid) is an inhibitor of VEGF-induced angiogenesis, cell migration and proliferation.

(E/Z)-10-Hydroxy-2-decenoic acid is a mixture of isomers of (E)-10-Hydroxy-2-decenoic acid (Royal Jelly acid). (E/Z)-10-Hydroxy-2-decenoic acid is an unsaturated medium-chain fatty acid that exhibits antibacterial activity against bacteria such as S. aureus (MIC = 23 μM) and inhibitory activity against L-02 and IMR-90 cells, with IC₅₀ values of 44 μM and 22.68 μM, respectively.

(E)-2-Decenoic acid (trans-2-Decenoic acid) is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees.