ro 31-8220 mesylate

Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.

Ro 31-8220 is a potent inhibitor of PKC with IC50 values of 5, 24, 14, 27, 24, and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε, and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β with IC50 values of 3, 8, 15, and 38 nM, respectively, without affecting MKK3, MKK4, MKK6, and MKK7.

Ro 31-8220 formic is a potent inhibitor of protein kinase C (PKC), specifically targeting PKCα, PKCβI, PKCβII, PKCγ, PKCε, and rat brain PKC, with IC50 values of 5, 24, 14, 27, 24, and 23 nM, respectively. It also inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β, with IC50 values of 3, 8, 15, and 38 nM. Additionally, Ro 31-8220 formic suppresses the expression of MKP-1, induces c-Jun expression, and activates JNK, exhibiting these effects through mechanisms independent of PKC.