resveratrol analog 2

Resveratrol analog 2 is an analog of Resveratrol, a natural polyphenolic phytoalexin with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

NQO2-IN-1, a resveratrol analog, is a potent quinone oxidoreductase 2 (NQO2) inhibitor (IC50=95 nM) with antitumor potential through the generation of ROS and up-regulation of DR5 (death receptor 5) to reverse trial resistance and promote apoptosis.

4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene) is a resveratrol analog that variably induces the expression of pro-apoptotic genes such as p53 and Bax. It triggers apoptosis in SV40 virus-transformed WI38 cells (WI38VA), but not in WI38 cells. Additionally, 4-Hydroxyresveratrol significantly increases the expression of p53, GADD45, and Bax genes in WI38VA cells, while suppressing the expression of the bcl-2 gene.