resibufogenin

1. Resibufogenin (Bufogenin) is a cytotoxic steroid isolated from the Chinese drug ChanSu. 2. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological effects on central nervous system. 3. Resibufogenin corrects hypertension in a rat model of human preeclampsia, it not only prevents the advent of hypertension and proteinuria, but also the development of intrauterine growth restriction.4. Resibufogenina's major metabolic pathway in the human liver is CYP3A4 dominantly mediated 5β-hydroxylation .

3-Oxo-resibufogenin is a bufadienolide with significant biological activity, exhibiting potential anticancer properties.

3-epi-Resibufogenin (compound 2) is an anticancer agent obtained through the biotransformation of Resibufogenin by Actinomucor elegans AS 3.2778. It demonstrates cytotoxicity against cancer cells, with IC50 values of 42.5 μM (A549) and 48.4 μM (H1299).

12β-Hydroxyresibufogenin, a bufadienolide, exhibits significant inhibitory activity against cancer cell lines.