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By Target- Potassium Channel
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Results for "
rac trans 4 hydroxy glyburide
" in TargetMol Product Catalog- Inhibitors & Agonists1
rac-trans-4-hydroxy Glyburide
T3563523155-00-2
rac-trans-4-hydroxy Glyburide, an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide, is formed by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. It inhibits glyburide binding to rat brain synaptosomes at high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.
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