puromycin aminonucleoside

Puromycin aminonucleoside (NSC 3056) is an aminonucleoside antibiotic and a purine analog of puromycin. It can reversibly inhibit dipeptidyl peptidase and cytosolic alanine aminopeptidase, increase podocyte permeability by regulating ZO-1 in an oxidative stress-dependent manner, induce apoptosis, and promote the secretion of migrasomes. It is commonly used to induce nephrotic syndrome models in research.

Puromycin-D3 dihydrochloride is the deuterated form of Puromycin dihydrochloride. Puromycin dihydrochloride (T2219) (CL13900 dihydrochloride) functions as an aminonucleoside antibiotic that inhibits protein synthesis.

Triptriolide inhibits puromycin aminonucleoside (PAN)-induced apoptosis in mouse podocytes by modulating Bcl-2 family proteins and suppressing Caspase-3. It also promotes cell survival and protects podocyte function by activating the TAK1-NF-κB signaling pathway and upregulating the podocyte protein podocin.