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Results for "
pteridine reductase-1 (ptr1)
" in TargetMol Product Catalog- Inhibitors & Agonists4
TbPTR1 inhibitor 2 
T933417557-67-4
TbPTR1 inhibitor 2 is identified as a new development of improved pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic agents[1].
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Insecticidal agent 19
T205222
Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folate metabolic pathway. This compound also inhibits the promastigote and amastigote forms of Leishmania major, with IC50 values of 1.43 μM and 3.78 μM, respectively.
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TbPTR1 inhibitor 1
T619122499713-65-2
TbPTR1 inhibitor 1 (compound 5d) is an effective inhibitor of kinetochore pteridine reductase 1 (PTR1). The IC50 of TbPTR1 inhibitor 1 against Trypanosoma brucei PTR1 (TbPTR1) is <0.1 nM, and its EC50 against Trypanosoma brucei is 0.66 μM.
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Antileishmanial agent-21
T79632
Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin. Additionally, it demonstrates inhibitory activity against the chloroquine-resistant Plasmodium falciparum strain RKL9, with an IC50 ranging from 0.0198 to 0.096 μM [1].
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