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Results for "

ptch1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    3
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • Antibody Products
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    TargetMol | Antibody_Products
Triparanol
NSC-65345, NSC65345, NSC 65345, MER-29
T2629678-41-1In house
Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.
  • $298
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Prostaglandin E1 ethanolamide
Alprostadil Ethanolamide
T84592210976-81-1
Prostaglandin E1 ethanolamide, an analog of Prostaglandin E1 (PGE1), can potentially inhibit the GLI2-induced expression of target genes such as Gli1 and Ptch1, thereby reducing tumor growth [1].
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8-10 weeks
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HL2-m5
TP31022130846-15-8
HL2-m5 is an inhibitor of the sonic hedgehog patched (Shh PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.
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