protac linker 2

Boc-C5-O-C5-O-C6-Cl (PROTAC Linker 2) is a chemical compound primarily used as a linker in PROTAC applications, facilitating the connection between a specific tyrosine kinase inhibitor (TKI) and the E3 recruiting ligand.

NH2-C2-NH-Boc (PROTAC Linker 22), an alkyl chain-based PROTAC linker, can be used in the synthesis of PROTACs.

NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs.

Triethylene glycol is a PEG-based PROTAC linker that can be used to synthesise PROTAC molecules.

Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a polyethylene glycol (PEG)-based linker used in synthesizing PROTACs, aiding in the targeted degradation of specific proteins [1].

Tos-PEG2-NH2 (PROTAC Linker 27) is a Polyethylene Glycol (PEG)-based linker utilized in the synthesis of Proteolysis-Targeting Chimeras (PROTACs) [1].

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29) is an alkyl ether-based linker used mainly for synthesizing PROTACs.

N3-PEG4-C2-NH2 is a PEG-type PROTAC linker that can be used in the synthesis of PROTAC molecules .This compound is a click chemistry reagent containing an Azide group.It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an Alkyne group,and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Phenol-amido-C1-PEG3-N3, also known as PROTAC Linker 21, is a PEG-based linker utilized for synthesizing PROTACs.

Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based linker suitable for the synthesis of PROTACs, which are compound complexes designed to selectively degrade target proteins[1].

Tos-PEG1-O-CH2COOH (PROTAC Linker 28) is a PEG-based linker used in the synthesis of PROTACs [1].

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker used in the synthesis of MT802 and SJF620, which are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively [1].

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

m-PEG2-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs.

NH2-C4-NH-Boc (compound 15) is a PROTAC linker of the Alkyl/ether class, suitable for synthesizing various PROTAC molecules.

NH2-C6-NH-Boc is a PROTAC linker used in the synthesis of the Mcl-1 inhibitor [based on PROTAC].

Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs

Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].

Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker employed in PROTAC synthesis [1].

Hydroxy-PEG4-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and can also be employed in the synthesis of PROTAC.

m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2].

NH2-PEG6-Boc is a PEG-based PROTAC linker used in PROTAC synthesis[1] and a non-cleavable 6-unit PEG ADC linker for antibody-drug conjugates (ADCs) synthesis[2].

2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide is an alkyl chain-based PROTAC linker used in PROTAC synthesis.