protac erα degrader1

PROTA CER Degrader-11 (Example 26-1) is an effective degrader of PROTA CER with an IC50 of 0.66 nM. It plays a crucial role in cancer research.

PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor/ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate.

PROTAC ER Degrader-15 (Compound 40) is an orally active estrogen receptor (ER) degrader with anticancer properties, suitable for breast cancer research.

PROTACER Degrader-12 (Compound 70) is an estrogen receptor PROTAC degrader with a degradation concentration (DC50) of less than 10 nM. It inhibits the proliferation of MCF-7 cells at a DC50 of under 10 nM and exhibits anticancer properties.

PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as a degrader of estrogen receptor-alpha (ERα).