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protac cdk9 degrader1

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  • Inhibitors & Agonists
    3
    TargetMol | All_Pathways
  • PROTAC Products
    3
    TargetMol | PROTAC
PROTAC CDK9 Degrader-1
T54382118356-96-8
PROTAC CDK9 Degrader-1 is a selective PROTAC CDK9 degrader composed of a cereblon ligand and a CDK9 ligand.
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PROTAC CDK9 degrader-11
T2056523039540-19-4
PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)
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PROTAC CDK2/9 Degrader-1
T125522408641-24-5
PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
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