propargyl-peg-10-acid

Propargyl-PEG10-acid, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by joining two essential ligands. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].