pre-mrna alternative splicing

HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibitor that blocks HIV replication.

RNA splicing modulator-4 (Compound A) is an orally active, brain-penetrant, and selective modulator of RNA splicing. It regulates alternative splicing events to control the inclusion or exclusion of specific exons in precursor mRNA (pre-mRNA), thereby altering the coding sequence and function of mature mRNA. RNA splicing modulator-4 is promising for research in neurodegenerative diseases (such as Huntington's disease) and cancer.

Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor that modulates pre-mRNA splicing to increase the expression of pro-apoptotic protein Mcl-1S and decrease Mcl-1L expression, without affecting the alternative splicing of Bcl-x. It synergizes with ABT-737 to induce apoptosis and demonstrates anticancer activity against non-small cell lung cancer.