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By Target- Antibacterial
- HIV Protease(2)
- Proteasome(2)
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Results for "
pr 957
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- ONX-0914PR-957, ONX0914, ONX 0914T6029960374-59-8ONX-0914 (PR-957) is a potent and highly specific immunoproteasome inhibitor with minimal cross-reactivity to the constitutive proteasome.
- $48
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Cited - ONX-0914 TFAT73986ONX-0914 (PR-957) TFA is a selective, noncompetitive, irreversible inhibitor of the chymotrypsin-like subunit (LMP7) of the immunoproteasome, effectively blocking cytokine production and mitigating experimental arthritis progression. With a K_i value of 5.2 μM against the mycobacterial proteasome, ONX-0914 TFA also reactivates latent HIV-1 by inducing p-TEFb activation through HSF-1 mediation [1] [2] [3].
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