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ponesimod

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Ponesimod
ACT-128800
T3258854107-55-4
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
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Ponesimod-d7
TMID-0871
Ponesimod-d7 (ACT-128800-d7) is the deuterium-labeled form of Ponesimod. It is an effective, selective, and orally active agonist of S1P1, with an IC50 value of 6 nM in radioligand binding assays. Ponesimod-d7 efficiently activates S1P1-mediated signal transduction with an EC50 of 5.7 nM and can prevent lymphocyte-mediated tissue inflammation.
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