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pomalidomide-peg-1-c2-n3

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Pomalidomide-PEG1-C2-N3
E3 ligase Ligand-Linker Conjugates 50, Cereblon Ligand-Linker Conjugates 13
T179042271036-44-1
Pomalidomide-PEG1-C2-N3, a conjugate of an E3 ligase ligand-linker, incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, commonly used in PROTAC technology. This compound enables the design of the selective CDK6 PROTAC degrader CP-10, which effectively induces CDK6 degradation with a DC50 value of 2.1 nM[1].
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