pneumococci

Trovafloxacin, a broad-spectrum quinolone antibiotic, exhibits potent activity against Gram-positive bacteria.

Trovafloxacin mesylate is a fluoroquinolone antibiotic and a dual inhibitor of DNA gyrase and topoisomerase IV, as well as a selective inhibitor of the Pannexin 1 channel (IC50 = 4 μM). With oral bioactivity and cell permeability, Trovafloxacin does not inhibit connexin 43 or PANX2, and is used for antibacterial therapy.

Clometocillin is a penicillin that can active penicillin to pen-I or pen-R pneumococci.

Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a penicillin that resists Penicillinase and exhibits antibacterial activity. It shows effective activity against Gram-positive cocci. Diphenicillin is promising for research on infectious diseases caused by Gram-positive bacteria such as staphylococci, pneumococci, and group A streptococci.