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(1)
By Target- Apoptosis
- IL Receptor(1)
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Results for "
pmbc
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Peptide Products1
Icotrokinra
PN-235, PN235, JNJ-77242113, JNJ77242113, JNJ-2113, JNJ2113
T890732763602-16-8
Icotrokinra is an orally bioavailable and highly selective antagonist of the interleukin-23 receptor (IL-23R), thereby interfering with IL-23-mediated signaling cascades. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 value of 5.6 pM, and it suppresses IL-23-induced interferon-gamma production in natural killer cells with an IC50 value of 18.4 pM. Icotrokinra further demonstrates anti-inflammatory effects in a rat TNBS-induced colitis model, making it a compound of interest in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease.
- $397
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