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By Target- Apoptosis
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- LPA Receptor
- LPL Receptor
- Melanin-concentrating Hormone Receptor (MCHR)
- Melanocortin Receptor
- Melatonin Receptor
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- Alangiaceae
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- Hydrolases,EC 3
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Results for "
pmbc
" in TargetMol Product Catalog- Inhibitors & Agonists2
Icotrokinra
PN-235,JNJ-77242113,JNJ-2113
T890732763602-16-8
Icotrokinra (JNJ-77242113) is an orally effective selective antagonist of the IL-23 receptor (IL-23 receptor), demonstrating high affinity with a dissociation constant (Kd) of 7.1 pM for the human IL-23 receptor (hIL-23R). It inhibits IL-23-induced STAT3 phosphorylation in PBMC with an IC50 of 5.6 pM and suppresses the production of IFNγ and IL-17A at the epidermal level induced by IL-23. Additionally, Icotrokinra exhibits anti-inflammatory activity in a rat model of TNBS-induced colitis.
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