plx-647

PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).

PLX647 dihydrochloride is a potent and selective dual inhibitor of FMS and KIT kinases, with IC50 values of 28 nM and 16 nM, respectively. At a concentration of 1 μM, PLX647 dihydrochloride demonstrates superior selectivity against a wide range of 400 kinases, except FLT3 and KDR, where IC50 values are 91 nM and 130 nM, respectively. This orally active compound holds great potential for targeted kinase inhibition.

PLX647(OMe) is a slightly less potent inhibitor of FMS than PLX647 but has better aqueous solubility.