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Results for "
pkc-412
" in TargetMol Product Catalog- Inhibitors & Agonists2
Midostaurin
PKC412, N-Benzoylstaurosporine, CGP41231, CGP 41251
T3211120685-11-2
PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
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O-Desmethyl Midostaurin
O-Desmethyl PKC412, CGP62221
T12280740816-86-8
O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.
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