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- COX(1)
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Results for "
phenacetin
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products1
Phenacetin
Acetophenetidin
T077862-44-2
Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.
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4,5-Dimethoxycanthin-6-one
Methylnigakinone
TN301318110-87-7
4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity against Staphylococcus aureus and its drug-resistant strains. It is a potent, non-competitive inhibitor of CYP1A2-mediated phenacetin O-deethylation (IC50: 1.7 μM, Ki: 2.6 μM) and a potent inhibitor of cyclic adenosine monophosphate (cAMP) phosphodiesterase. Additionally, it exhibits cytotoxicity to tumor cell lines U937 and HepG2.
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