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Results for "
pf06273340
" in TargetMol Product Catalog- Inhibitors & Agonists1
PF-06273340
PF-6273340, PF6273340, PF 6273340, PF 06273340
T196491402438-74-7
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1).
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