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By Target- Aurora Kinase
- CDK(1)
- Chk(1)
- FGFR(1)
- FLT(1)
- Src(1)
- VEGFR(1)
- c-Fms(1)
- c-RET(1)
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Results for "
pf-00477736
" in TargetMol Product Catalog- Inhibitors & Agonists2
PF 477736
PF-477736, PF477736, PF 00477736
T6028952021-60-2
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
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PF-477736 2HCl
T2029681247874-19-6
PF-477736, also known as PF-00477736, is a potent CHK1 inhibitor with potential to enhance chemotherapy. This compound inhibits CHK1, an ATP-dependent serine threonine kinase that is a crucial component of the S G2 checkpoint system for DNA replication monitoring. By bypassing the final checkpoint defenses against DNA damage-induced lethal effects, PF-477736 may improve the antitumor efficacy of various chemotherapeutic agents in tumor cells with inherent checkpoint deficiencies.
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