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By Target- Acetyl-CoA Carboxylase
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Results for "
pf 05221304
" in TargetMol Product Catalog- Inhibitors & Agonists2
PF-05221304
STAT5 Inhibitor III, NSC 170984, R 6238,, Clesacostat
T92091370448-25-1
PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
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Clesacostat tromethamine
QF09CQF4SR, PF-05221304 tromethamine
T2027452334472-62-5
Clesacostat (PF-05221304) is a potent and selective ACC inhibitor, with hACC1 IC50 of 13 nM and hACC2 IC50 of 9 nM. In animal models, PF-05221304 specifically inhibits hepatic DNL and demonstrates a significant safety margin for thrombocytopenia in non-human primate models.
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