pd149163

SMTIN-P01 is a mitochondria-targeted Hsp90 inhibitor. It is made from the isopropyl amine of the Hsp90 inhibitor PU-H71 being replaced with the mitochondria-targeting moiety triphenylphosphonium.

PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cognitive, anti-psychotic and anxiolytic effects.

PD-149163 hydrochloride is a neurokinin agonist with antipsychotic activity. It modulates bacterial endotoxin-induced neuroinflammation in mice and can be used in neurological disease research.

Lipopolysaccharides from *E. coli* (Escherichia coli) O26:B6 are endotoxins derived from *E. coli* that function as TLR-4 activators. These S-type LPS molecules can trigger pathogenic-associated molecular patterns (PAMP) and encourage the release of exosomes. Structurally, they are composed of three parts: O-antigen, core oligosaccharide, and Lipid A, and can be identified by the monoclonal antibody MAb J8-4C10. This compound can increase pro-inflammatory cytokines in plasma, leading to activation of the hypothalamic-pituitary-adrenal (HPA) axis and causing oxidative damage to the adrenal glands. However, the pathogenic activity of Lipopolysaccharides from *E. coli* O26:B6 can be inhibited by PD149163 (HY-123434).