paromomycin

Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate (Aminosidine sulfate) is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria.

6 '-Deamino-6 '-hydroxyparomomycin I is an aminoglycoside antibiotic produced by Streptomyces rimosus forma paromomycinus A67 15, exhibiting activity against both Gram-positive and Gram-negative bacteria. It serves as an intermediate in the biosynthesis of paromomycin.

6-Deoxyparomomycin exhibits antibacterial activity.

Paromomycin II is an aminoglycoside antibiotic that exhibits activity against both Gram-positive and Gram-negative bacteria, mycobacteria, and protozoa. It is particularly effective in treating amoebic dysentery and certain bacterial dysentery cases.