palmitoylethanolamide

Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant.Upon administration, palmitoylethanolamide may inhibit the release of pro-inflammatory mediators from activated mast cells.

Palmitoylethanolamide-d4 is the deuterated version of Palmitoylethanolamide. Palmitoylethanolamide (Palmidrol) is an endogenous bioactive compound utilized for the prevention of respiratory viral infections.

Palmitoylethanolamide-d5 (Palmidol-d5, PEA-15,15,16,16,16-d5) is the deuterium-labeled form of Palmitoylethanolamide. Palmitoylethanolamide (Palmidrol) is an endogenous bioactive compound that may be employed to prevent respiratory viral infections.

NAAA-IN-2 (Compound 9), a potent and selective inhibitor of NAAA, exhibits an IC50 of 50 nM. NAAA, a cysteine amidase, primarily breaks down the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). This compound demonstrates promise for inflammation and pain research [1].

NAAA-IN-3 (Compound 17a) is a potent and selective NAAA inhibitor with an IC50 of 50 nM. NAAA is a cysteine amidase that preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). PEA is an endogenous agonist of the nuclear peroxisome proliferator-activated receptor-α (PPAR-α), a key regulator of inflammation and pain. The potential role of NAAA-IN-3 is as a therapeutic agent for the treatment of inflammation and pain.

NAAA-IN-1 (Compound 1) is a potent and selective NAAA inhibitor (IC50 = 7 nM) that can be used in inflammation and pain research. NAAA, a cysteine amidase, preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) [1].

Palmitoleoyl Ethanolamide (POEA) is an endogenous fatty acid ethanolamide (FAE) and a member of the endocannabinoid-like family of molecules. It is a derivative of the monounsaturated fatty acid palmitoleic acid. Similar to the well-studied palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), POEA is thought to exert biological effects by modulating peroxisome proliferator-activated receptor α (PPAR-α), G protein-coupled receptors (e.g., GPR119), or through the "entourage effect" by modulating endocannabinoid signaling. It has demonstrated potential activities in anti-inflammation, analgesia, and metabolic regulation.