p450 2a6

Isoglycycoumarin, a flavonoid derived from the roots of Glycyrrhiza uralensis, serves as a highly selective probe for human cytochrome P450 2A6.

DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6), significantly reducing self-administered nicotine doses in both male and female mice.

SM 12502 serves as a substrate for cytochrome P450 2A6 in human liver microsomes.

LKY-047, a derivative of Decursin, is a highly effective and specific reversible competitive inhibitor of cytochrome P45022J2 (CYP2J2), with an IC 50 value of 1.7 μM. LKY-047 does not display inhibitory activity against other human P450 enzymes including CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A.

4-Ethylbenzonitrile is a micromolar level inhibitor of Cytochrome P450 2A6 with an IC50 value of 7.4 μM.