oxygen sensing

2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)

5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II) (commonly known as CoTPP) is a coordination compound. Known for its distinct electronic and optical properties, it is widely employed in fields such as catalysis, sensing, and organic electronics. It serves as an efficient catalyst in numerous chemical reactions, including oxidation, reduction, and CH bond activation. Additionally, CoTPP is used as a fluorescent probe for detecting oxygen levels in biological systems and as an active material in organic solar cells.

HIF-2a translation inhibitor is a potent HIF-2α translation inhibitor with IC50=5 μM that inhibits constitutive and hypoxia-induced HIF-2α protein expression. Among them, HIF-2α-IN-4 associates the 5'UTR iron response element with oxygen sensing.