orotidine 5′monophosphate

Orotidine 5′-monophosphate, a pyrimidine ribonucleoside, functions as an endogenous metabolite in human, E. coli, and mouse processes. It serves as an intermediate in uridine monophosphate (UMP) biosynthesis and is utilized in researching the mechanism of orotidine 5′-monophosphate decarboxylase.

Orotidine 5'-monophosphate trisodium, a pyrimidine nucleotide, is synthesized through the de novo DNA synthesis pathway by various microorganisms, including M. tuberculosis, S. cerevisiae, S. typhimurium, and P. falciparum. The compound's production involves orotate phosphoribosyltransferase (OPRT)-catalyzed reactions using phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as substrates [1].