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Results for "
org 24598 lithium
" in TargetMol Product Catalog- Inhibitors & Agonists1
Org 24598 lithium salt
T37700722456-08-8
Org 24598 lithium salt is a GlyT-1 inhibitor of glycine transporter 1. Org 24598 lithium salt inhibits the specific binding of [3H]CHIBA-3007 to rat meninges (Ki=16.9 nM).
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T37699372198-97-5
Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo.
Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 |Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID:11454468 |Williams et al (2003) Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 321 31 PMID:12963052
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