orally ethanol

LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM).

Calcium 4-Oxopentanoate (calcium levulinate) is an orally effective calcium supplement commonly used as a food additive. In the liver, it is reduced to form 4-hydroxypentanoate, a process enhanced by ethanol. Calcium 4-Oxopentanoate is also employed in studies related to calcium deficiency.

MY10, a potent and orally active inhibitor of the receptor protein tyrosine phosphatase (RPTPβ/ζ), effectively reduces binge-like ethanol consumption and diminishes the rewarding effects of ethanol.