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By Target- DNA Alkylator/Crosslinker
- Dehydrogenase(1)
- Others(1)
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Results for "
obi-3424
" in TargetMol Product Catalog- Inhibitors & Agonists2
OBI-3424
T223882097713-68-1
OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.
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Odafosfamide
AST-3424, (S)-TH-3424, (S)-OBI-3424
T2117032097713-69-2
Odafosfamide ((S)-OBI-3424) is a highly selective prodrug bi-alkylating agent activated by aldo-keto reductase 1C3 (AKR1C3). It exhibits potent cytotoxicity in cell lines with high AKR1C3 expression. Odafosfamide demonstrates antitumor activity in various tumors with elevated AKR1C3 expression, such as liver cancer, non-small cell lung cancer, and leukemia. It is applicable for cancer research.
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