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By Target- DNA Alkylator/Crosslinker
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Results for "
obi-3424
" in TargetMol Product Catalog- Inhibitors & Agonists2
OBI-3424
T223882097713-68-1
OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.
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Odafosfamide
AST-3424, AST3424, (S)-TH-3424, (S)-TH3424, (S)-OBI-3424, (S)-OBI3424
T2117032097713-69-2
Odafosfamide ((S)-OBI-3424) is a highly selective prodrug bis-alkylating agent that is specifically activated by aldehyde-keto reductase 1C3 (AKR1C3), resulting in pronounced cytotoxicity toward tumor cell lines with elevated AKR1C3 expression, and it demonstrates significant antitumor activity in cancers such as liver cancer, non-small cell lung cancer, and leukemia, making it a targeted and mechanistically informative compound for precision oncology research.
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