nt 157

Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg mL, exhibiting both anti-inflammatory and anticancer effects. It interacts with inducible NO synthase (iNOS) and caspase 8, which facilitates apoptosis through nuclear fragmentation and chromatin condensation. Additionally, Anticancer Agent 157 effectively inhibits HT29 colon cancer cells (IC50 =2.45 μg mL), Hep-G2 liver cancer cells (IC50 =3.25 μg mL), and B16-F10 murine melanoma cells (IC50 =3.84 μg mL) [1].

Compound B12 (Antibacterial agent 157) is a fungicidal agent that can impact protein synthesis in Botrytis cinerea. It is utilized in research for controlling gray mold resistance [1].

NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.