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Results for "
nsc 336628
" in TargetMol Product Catalog- Inhibitors & Agonists1
Merbarone
RLBN-1001, RLBN1001, NSC-336628, NSC336628
T2801797534-21-9
Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.
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