nik smi 1

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

(S)-NIK SMI1 is the isomer of NIK SMI1 and can be used as a control compound in experiments. NIK SMI1 serves as a potent and selective inhibitor of NF-κB-inducing kinase (NIK), effectively blocking the NIK-catalyzed hydrolysis of ATP to ADP, with an IC50 of 0.23±0.17 nM.