nidulin

Nidulin is a depsidone originally isolated from A. nidulans. It is active against the bacteria M. tuberculosis and M. ranoe, as well as the fungi T. tonsurans and M. audouini. It also inhibits the growth of methicillin-resistant S. aureus (MRSA; MIC = 4 μg/ml) and has larvicidal activity toward Artemia (LC50 = 2.8 μg/ml). Nidulin is cytotoxic to MOLT-3 cells (IC50 = 21.2 μM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >112.7 μM). It inhibits aromatase with an IC50 value of 11.2 μM.

Nornidulin is a depsidone originally isolated from [A. nidulans] with antibacterial activity against [M. tuberculosis] and [M. ranoe], and antifungal activity against [T. tonsurans] and [M. audouini]. It inhibits the growth of methicillin-resistant [S. aureus] (MRSA; MIC = 2 μg/ml) and has larvicidal activity toward Artemia (LC50 = 1.7 μg/ml). Nornidulin exhibits cytotoxic activity in MOLT-3 cells (IC50 = 35.7 μM) but not in HuCCA-1, HepG2, or A549 cells (IC50s = >116.4 μM).