nh2 peg2 c2 boc

NH2-PEG2-C2-Boc is a polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTACs[1] and serves as a non-cleavable 2-unit PEG linker for antibody-drug conjugates (ADCs)[2].

Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based linker used in PROTAC synthesis, essential for connecting the targeted protein and the E3 ubiquitin ligase to facilitate selective protein degradation[1].

JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.

Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc is a conjugate combining an E3 ligase ligand with a linker, featuring a Thalidomide-based CEREBLON ligand and a PEG linker. It serves as a component in the synthesis of the PROTAC degrader JB300.