neuraminidasein1

Neuraminidase-IN-1 (Compound Y-1) is a novel neuraminidase inhibitor.

Neuraminidase-IN-15 is an inhibitor of neuraminidase, effectively suppressing the activity of La Sota Clone 30 NDV-HN with an IC50 value of 0.06 µM. Neuraminidase-IN-15 is applicable for studies on Newcastle disease virus (NDV).

Neuraminidase-IN-19 (compound 5n) is a neuraminidase inhibitor featuring a thiophene ring, with an IC50 of 0.13 μM, and exhibits anticancer cell activity.

Neuraminidase-IN-10 is a neuraminidase inhibitor that exhibits anti-influenza effects and is able to act on H1N1 (IC50: 2.6 nM), H5N1 (IC50: 5.1 nM) and H5N8 (IC50: 1.65 nM).

Neuraminidase-IN-11 (15e) is a selective and potent neuraminidase (NA) inhibitor, effective against the neuraminidase of H1N1 virus (IC50: 4.7 nM), H5N1 virus (IC50: 8.46 nM), and H5N8 virus (IC50: 1.5 nM).

NDV-IN-1 is an antiviral agent with high neuraminidase inhibitory activity, demonstrating significant in vitro inhibitory effects against Newcastle disease virus (NDV). It effectively prevents NDV infection of Vero cells by inhibiting the release of virus particles from infected cells [1].

Neuraminidase-IN-16 (Compound 43b) serves as a potent inhibitor of neuraminidase, demonstrating IC50 values of 0.031, 0.15, 0.25, 0.60, 0.63, and 10.08 μM against neuraminidase from H5N1, H5N8, H1N1, H3N2, H5N1–H274Y, and H1N1–H274Y strains, respectively [1].

Neuraminidase-IN-13 (Compound 10), a neuraminidase inhibitor exhibiting antiviral activity, demonstrates significant inhibition of NDV infection in Vero cells with minimal cytotoxicity by impeding the release of viral particles from infected cells [1].

Neuraminidase-IN-17 (compound N10), characterized as a neuraminidase inhibitor, demonstrates an EC 50 of 0.11 μM and exhibits antiviral activity in vitro [1].

Neuraminidase-IN-18 (compound N5), a novel polyheterocyclic neuraminidase (NA) inhibitor, demonstrates significant inhibitory activity against H5N1 NA, with an IC 50 of 0.14 μM against the wild-type H5N1 NA and 0.27 μM against the H5N1-H274Y mutant NA. This compound effectively binds to NAs, inhibiting influenza virus replication at the cellular level [1].