nesosteine lithium

Nesosteine Lithium is a novel mucoregulatory that inhibits Herxheimer microconvulsions in guinea pigs and inhibits ovalbumin-induced histamine release from sensitized trachea.Nesosteine Lithium protects against ovalbumin-induced bronchospasm but is ineffective against histamine- and acetylcholine-induced bronchospasm. Nesosteine Lithium protected against ovalbumin-induced bronchospasm but not histamine- and acetylcholine-induced bronchospasm.

Nesosteine is a mucoregulatory agent.

Nesosteine sodium salt is an effective bronchitis inhibitor that enhances the rheology and production of bronchial mucus in rabbits. When administered via sulfuric acid nebulization in animals with induced bronchitis, this compound significantly reduces the viscosity of bronchial mucus and increases mucus production in healthy animals. It exhibits greater activity compared to other mucoregulatory drugs, such as Sobrerol, N-acetylcysteine, bromhexine, ambroxol, S-carboxymethylcysteine, and thiopropamine. Additionally, Nesosteine sodium salt reduces the total protein content in the airway bronchial mucus, including albumins and mucoproteins α1, α2, β, and γ.