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Results for "
nemadipine a
" in TargetMol Product Catalog- Inhibitors & Agonists2
Nemadipine-A
T3572954280-71-6
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
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Nemadipine B
T8921479925-38-5
Nemadipine B is a calcium channel blocker and an antagonist of EGL-19. It induces Egl, Vab, and Gro phenotypes in Caenorhabditis elegans.
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