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Results for "
nas181
" in TargetMol Product Catalog.- Inhibitors & Agonists4
- NAS-181 free baseT69959205242-61-1NAS-181 free base is a 5-HT(1B) receptor antagonist.
- $1,970
SizeQTY - Tofacitinib maleateT699582052885-67-1Tofacitinib maleate, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib maleate modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib maleate inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.
- $1,520
SizeQTY - NAS-181T62585205242-62-2NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM), which enhances the accumulation of 5-HTP in rat brain regions.
- $10,568
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